KPNA2 and gastric cancer: Moreover, KPNA2 was markedly decreased in patients displaying metastasis to the lymph node (p < 0.001) and more advanced pathologic stages (III and IV) of GC, compared to earlier pathologic stages (I and II) (p < 0.001), as well as those with peritoneal seeding (p < 0.001), vascular invasion (p < 0.001), lymphatic invasion (p < 0.001) and perineural invasion (p < 0.001).