KPNA2 was more significantly downregulated in T3 and T4 groups whereby the serosal surface of the gastric wall was invaded by cancer, compared to T1 and T2 groups with no evident invasion (p < 0.001), as well as in relation to higher lymph node status (p < 0.001), lymph node metastasis (p < 0.001) and distant metastasis (p < 0.001). The gene discussed is KPNA2; the disease is metastatic malignant neoplasm in the lymph nodes.