Furthermore, the mathematical model is minimal in the sense that includes just the plasminogen system (of uPA, uPAR, PAI-1), plasmin and MMP, tissue factor, VEGF, MCP-1, M-CSF, and the cells that produce these proteins or are activated by them, namely, macrophages, endothelial cells, fibroblasts and cancer cells. The gene discussed is CSF1; the disease is cancer.