SERPINE1 and neoplasm: There are three terms in the bracket: The first term is for tumor growth at rate which is oxygen dependent; the second term represents enhancement by EGF produced by fibroblasts; the third term accounts for proliferation of cancer cells by uPA as it binds to its receptor uPAR on cancer cells [11, 12, 15, 36], a process resisted by PAI-1 [14, 16].