In H9c2 cells, the DSVs only identified in MI patients or the DSVs found in MI patients with higher frequencies, g.237307A>G, g.237270G>A+g.236370C>G+g.236380_81ins, g.237030C>T (rs12293349), g.237023_25del, g.237022C>G (rs369344513), g.236653C>A+g.236473C>T and g.236628G>C, significantly repressed the transcriptional activities of the SIRT3 gene promoter to different extents (P<0.05, Fig 4). Here, SIRT3 is linked to myocardial infarction.