These included well-known ATRA target genes: Dhrs3, Cyp26a1, Cyp26b1, Rarγ, Rarβ, Crabp2, and Stra6. Several of the same ATRA-sensitive genes were downregulated in mouse models of UVB-induced SCC and BCC (Fig 8B and 8C). Here, DHRS3 is linked to skin basal cell carcinoma.