These included well-known ATRA target genes: Dhrs3, Cyp26a1, Cyp26b1, Rarγ, Rarβ, Crabp2, and Stra6. Several of the same ATRA-sensitive genes were downregulated in mouse models of UVB-induced SCC and BCC (Fig 8B and 8C). The gene discussed is CYP26A1; the disease is skin basal cell carcinoma.