Our predicted NFκB pathway suggested 8 novel genes which were found to be highly down-regulated in lethal prostate cancer and highly functionally related to NFκB, namely ATF3, CXCL2, DUSP5, JUNB, NEDD9, SELE, TRIB1, and ZFP36 (Table 1). The gene discussed is TRIB1; the disease is Familial prostate cancer.