NFKB1 and metastatic neoplasm: Surprisingly, none of the NFκB genes were significantly differentially expressed (NFκB1: FDR = 0.69, NFκB2: FDR = 0.19, REL: 0.60, RELB: FDR = 0.71, RELA: FDR = 0.91) (S7 Table), which could be a result of their constitutive activation, negative feedback loops, or the presence/absence of cancer regulator genes that determine whether it promotes cancer to develop metastatic disease [7].