In this novel NFκB pathway we identified novel roles for ATF3, CXCL2, DUSP5, JUNB, NEDD9, SELE, TRIB1, and ZFP36 in this pathway, and predicted novel upstream regulators (ATF3, JUNB, KLF6, NR4A2, ZFP36, DUSP5 NEDD9, STAT3, and IRF1) and downstream targets (SELE, CXCL1 and CXCL2) of NFκB in prostate cancer, along with 70 (out of 112) novel mechanistic interactions (S17 Table). This evidence concerns the gene IRF1 and Familial prostate cancer.