Notable genes in the predicted pathway included ATF3, JUNB, KLF6, NR4A2, ZFP36, DUSP5 and NEDD9, as well as STAT3 and IRF1 as novel upstream regulators, and SELE, CXCL1 and CXCL2 as novel downstream targets of NFκB in prostate cancer. The gene discussed is ATF3; the disease is Familial prostate cancer.