Notable genes in the predicted pathway included ATF3, JUNB, KLF6, NR4A2, ZFP36, DUSP5 and NEDD9, as well as STAT3 and IRF1 as novel upstream regulators, and SELE, CXCL1 and CXCL2 as novel downstream targets of NFκB in prostate cancer. This evidence concerns the gene STAT3 and Familial prostate cancer.