NFKB1 and Familial prostate cancer: Although there exist several pathway collections and databases (e.g. BioCarta, KEGG [85], Reactome [86], NCI Pathway Interaction Database [87]), most focus on pathways that are gene-specific (e.g. the NFκB signaling pathway from BioCarta or Cell Signaling Technology [6,16–18]) rather than disease- or tissue-specific [such as the prostate cancer pathway from KEGG (hsa05215) [88–91]].