REL and Familial prostate cancer: In this pathway we show 10 known NFκB pathway genes (NFκB1, NFκB2, REL, RELA, RELB, IκB-α, IκB-ε, IKK-α, IKK-β, and IKK-γ; S16 Table), along with 8 novel genes that we found to be significantly down-regulated in lethal versus indolent prostate cancer in publically available databases [25,26] and that were highly functionally associated with NFκB in multiple biological contexts (Tables 1 and S12).