Additionally, we recovered genes that previously have been reported to be associated with NFκB or prostate cancer (TNF-α/TNFAIP3, STAT3, MAP3K8, NR4A2/NR3C4, BCL2, and IL18; S16 and S17 Tables), as well predicted novel upstream regulator genes (ATF3, JUNB, KLF6, NR4A2, ZFP36, DUSP5 and NEDD9, and IRF1) and downstream target genes of NFκB (SELE, CXCL1 and CXCL2; S16 Table) which may be involved in the NFκB pathway for development and progression of lethal prostate cancer as detailed below. The gene discussed is IL18; the disease is Familial prostate cancer.