Our predicted NFκB pathway (Fig 2) revealed 8 genes highly down-regulated in lethal prostate cancer and highly functionally related to NFκB (Table 1), including novel upstream regulators (ATF3, JUNB, KLF6, NR4A2, ZFP36, DUSP5, NEDD9, STAT3 and IRF1) and novel downstream targets (SELE, CXCL1 and CXCL2) of NFκB in prostate cancer. Here, IRF1 is linked to Familial prostate cancer.