AREG and Familial prostate cancer: Additionally, we observed strong functional enrichments in the extracellular space, a major component in cancer development and progression [29]) for AREG [30,31], SELE [32], LIF [33], and several chemokines and cytokines [34–38], as well as high disease enrichment (NCI Cancer Gene Index) in 47 different cancer associations from all major tissues (S13B Table), indicating that these genes are not only involved in prostate cancer, but also in a variety of other cancer types.