In another study, Xavier et al. generated heterozygous mice with endothelium-specific knock-out of the TGF-receptor II (TβRII) gene and demonstrated that the resulting partial TβRII deletion abrogated EndoMT and reduced tubulointerstitial kidney fibrosis in two murine models of renal fibrosis [85]. The gene discussed is TGFBR2; the disease is renal fibrosis.