The role of NOX4 as an important downstream mediator of TGF-β-induced myofibroblast generation, its contribution to the potent TGF-β profibrotic effects, and its participation in the pathogenesis of tissue fibrosis in various fibrotic disorders such as IPF and liver fibrosis have been recently demonstrated [135,136,137,138,139,140,141,142,143,144]. Here, TGFB1 is linked to Hepatic fibrosis.