Beyond hyperinsulinemia, uric acid is responsible of mitochondrial oxidative stress [29], sterol regulatory element-binding protein 1 (SREBP-1) activation induced by endoplasmic reticulum (ER) stress [30] and NLRP3 inflammasome involvement [31], all causative factors of lipid metabolism impairment. The gene discussed is SREBF1; the disease is hyperinsulinism.