To investigate the bacterial infection-mediated innate immunity in allergic inflammation, the expression and cytokine inducing function of TLR2 and NOD2 of basophils, circulating antimicrobial peptide HNP and dermcidin and the AD-related chemokines CCL17, CCL22 and CCL27 were evaluated in the present cross-sectional clinical study. This evidence concerns the gene CCL22 and Alzheimer disease.