TP53 and neoplasm: Previously, we and other groups have shown that Wip1 induction decreased the level of histone γH2AX phosphorylation in the course of DNA damage in tumor cell lines.16, 17, 18, 19, 20 We hypothesized that we could achieve p53-negative cells sensitization with simultaneous normal cell protection by targeting kinases that affect the Wip1–γH2AX pathway, directly or indirectly.