At that concentration, it has been shown that MK-1775 can inhibit Wee1 only by 50%.32 On the contrary, in the absence of doxycycline-induced Wip1 overexpression, MK-1775-mediated sensitization (P=0.0201) of tumor cells to cisplatin was significantly attenuated. This evidence concerns the gene PPM1D and neoplasm.