TLR3 and breast cancer: Interestingly, the gene sets of ISs (AIM2, IFIH1 and TLR3), ISs and IFN-β (IFNB1), and all (ISs, IFNB1, IRF7 and TRAIL) showed strong correlations in ER-negative and lymph node positive or basal-like breast cancer patient survival (Figure 6d and e).