PRKCA and metastatic malignant neoplasm: The live MDA cells after act hMSC coculture showed decreased expression of protein kinase C-alpha (PKC-α), whereas rhTRAIL treatment increased PKC-α (Figure 1j), which is highly expressed in metastatic cancer cells.29, 30, 31 These data suggest that act hMSCs not only induce cancer cell death but also suppress metastatic features of MDA cells through coculture.