CAPN2 and Hypertension: Pharmacological inhibition of calcium channels using the FDA-approved drug verapamil was reported to successfully restore autophagic flux and reduce steatohepatitis.27 As calcium channel blockers have been safely used clinically for >30 years for the treatment of hypertension, whether it can suppress calpain 2 activity and reduce fatty liver I/R injury would be an interesting clinical topic.