Interestingly, not only do viruses appear to exploit a glycan shielding strategy, but also cancer cells show aberrant expression of sialic acid-modified glycans that are thought to play a role in tumor immune evasion [32], which may in part be due to the reported sialylation-dependent inhibition of NK cells by masking ligands of activating NK cell receptors [33]. Here, KLRD1 is linked to neoplasm.