Particularly, our recent finding that CXADR is required for adherens junction (AJ) and TJ assembly during porcine blastocyst formation (Kwon, Kim & Choi, 2016) also supports this hypothesis, because CXADR was reported to be directly associated with ROCK in human tumor cells (Saito et al., 2014). This evidence concerns the gene CXADR and neoplasm.