In our study, patients with p16INK4A overexpression have a better prognosis, are correlated with less lymph node metastasis (p = 0.038), and are frequently associated with lower-grade TNM stage (p = 0.147), which are in accordance with previous studies [21, 26, 32]. This evidence concerns the gene CDKN2A and metastatic malignant neoplasm in the lymph nodes.