Therefore, we next examined the contribution of NF-κB, JNK, and p38 to necrotic cell-induced IL-8 expression, migration and invasion in glioblastoma cells, using specific inhibitors for NF-κB, JNK, and p38: BAY 11-7082 for NF-κB, SP600125 for JNK, and SB203580 for p38. The gene discussed is NFKB1; the disease is glioblastoma.