FeNO can also associate with metabolic disease through asymmetric dimethylarginine (ADMA), a common link between oxidative stress, inflammation and metabolic syndrome, by competing for binding to Endothelial Nitric Oxide Synthase (eNOS) with L-arginine and synthesizing high levels of NO and alteration in NO has also been related to mitochondrial dysfunction, a potential pathogenic mechanism for metabolic dysfunction38. This evidence concerns the gene NOS3 and metabolic syndrome.