Protein kinase C epsilon (PKCε)7, Bcl-28, insulin growth factor 1 (IGF-1)11 and heat shock protein 60 (Hsp60)7, 12 have been verified as target genes of miR-1 that mediate the effect of miR-1 in aggravating myocardial injury by I/R or infarction. The gene discussed is HSPD1; the disease is infarction.