Our preclinical studies demonstrated that SDS protects rat from HFHC diet -induced NASH through suppressing the oxidative stress-induced liver damages, as evidenced by the results that SDS significantly reduced the increased MDA and increased the suppressed antioxidation enzymes, like SOD, GSH, GPX, and CAT, in the NASH-injured liver. This evidence concerns the gene SOD1 and metabolic dysfunction-associated steatohepatitis.