The current results demonstrated that SDS can suppress the increased CYP2E1 and Nox2 expression, suggesting that SDS may exert the hepatoprotective effect through inhibition of the CYP2E1/Nox2 coupling reaction, reducing oxidative stress, and ameliorating liver injury caused by NASH. This evidence concerns the gene CYP2E1 and metabolic dysfunction-associated steatohepatitis.