GNRH1 and ovarian carcinoma: In light of these findings, in our previous studies [13], we chose film-forming materials as the shell, and fluothane as the core to obtain nontargeting nanobubbles (N-NBs) via freeze-drying method, and then, the LHRH antibody was linked to the surface of the nanobubble via biotin–avidin binding method to prepare ovarian cancer-targeting nanobubbles (LHRH-NBs).