On the other hands, Cd40-/- mice showed greater reduction in the development of psoriasiform skin inflammation than Cd80−/−Cd86−/− mice35 when compared with WT mice (Supplementary Fig. 11), indicating that costimulation between T cells and APCs is necessary for the formation of psoriasiform dermatitis. The gene discussed is CD80; the disease is Psoriasiform dermatitis.