Our data showed a clear decrease in Nrp-1 obviously in IL10-deficient tumor-bearing mice (Fig. 4D), and the number of CD4+Foxp3+Nrp-1+ T cells obtained from the spleen (Fig. 4E) was significantly decreased in IL10−/− B16/F10 mice based on flow cytometry analysis26. The gene discussed is IL10; the disease is neoplasm.