In addition, the phosphorylation of STAT1 (Tyr701 and Ser727) was also strikingly inhibited by PD98059 and U0126 in the AML cells, indicating that the TAK165 and ATRA combination treatment-induced activation of STAT1 was dependent on the activation of the MEK/ERK-cascade. The gene discussed is MAP2K7; the disease is acute myeloid leukemia.