In conclusion, we conducted this study to describe the gene mutation profiling in stage II/III colon cancer in Eastern Asia populations, PIK3CA (E545K) mutation was independently prognostic for OS in stage III and different subtypes of gene mutants should be further investigated in colon cancers, additional analysis with these molecular prognostic factors may provide a better insight and help us understand the mutation profiling in the evolution of this disease. This evidence concerns the gene PIK3CA and colonic neoplasm.