Interestingly, ChIP-Seq assays performed in human HEL leukemia cells revealed that JAK2V617F-induced constitutive active STAT5 [47, 48] is bound at c-Myc enhancer region E3 (ArrayExpress accession number E-MTAB-1096; [49]), providing another evidence of STAT5 constitutive binding at c-Myc super-enhancer in leukemia cells. Here, STAT5A is linked to leukemia.