SOD1 and amyotrophic lateral sclerosis: In particular, Khare and Dokholyan have carried out a computational analysis of 75 different SOD1 mutants implicated in familial ALS and their impact on dimer association thermodynamics (69) and found that 70 of these lead to either decreased dimer stability or increased dimer dissociation or both, whereas 4 of them lead to decreased monomer stability.