We found that celecoxib significantly inhibited adhesion and invasion in all three ovarian cancer cells tested and reduced MMP9 protein expression, PGE2 production and blood vessel density in the ovarian tumors from obese and non-obese KpB ovarian mice, suggesting that celecoxib has both anti-tumorigenic and anti-metastatic effects in ovarian cancer. This evidence concerns the gene MMP9 and ovarian cancer.