However, in the FLT3 wild-type (wt) expressing cell lines, OCI-AML-3 and U937, phosphorylation of FLT3 Y589/591 were not detected and phosphorylation of STAT5 as well as cMyc expression were unaffected, except the AKT kinase mediated signaling pathway (Supplementary Figure 4). Here, FLT3 is linked to acute myeloid leukemia.