FLT3 and acute myeloid leukemia: The clonogenic assay also confirmed the selective efficacy of A674563 against FLT3-ITD positive AML cell lines (MV4-11, EC50: 0.092 μM; MOLM13, EC50: 0.17 μM; MOLM14, EC50: 0.061 μM) compared to FLT3-wt expressing cell lines (PF382, EC50: 0.861 μM; U937, EC50: 0.505 μM; HL-60, EC50: 0.387 μM) (Supplementary Figure 1).