A674563 exhibits potent activity against FLT3-ITD positive AML cancer cells in vitro and in vivo through selective, dual inhibition of AKT and FLT3 kinases, and is also capable of overcoming FLT3 ligand-induced drug resistance in FLT3 wt/ITD co-expressing cells. This evidence concerns the gene FLT3 and acute myeloid leukemia.