TNF and infection: In this study, we observed a migration of CD4+ T lymphocytes to the lungs inall groups challenged with Mtb, demonstrating that infection alone was capable ofinducing the migration of these cells (Fig. 3).However, when evaluating the profile of the Th1 cytokines produced by these cells in thelung, we found that IFN-g and TNF-a were increased in the mice immunised with themc2-CMX vaccine compared to the group immunised with the BCG vaccine(Fig. 3A, B).