FLT4 and colitis: When acute colitis was induced in mice overexpressingVEGF-C, there was a significant increase in colonic epithelial damage, inflammatoryedema, microvessel density, and neutrophil infiltration compared to control mice.These mice also exhibited increased lymphatic vessel density (73.0±3.9vs 38.2±1.9, P<0.001) and lymphatic vessel size (1974.6±104.3vs 1639.0±91.5, P<0.001) compared to control mice.Additionally, the expression of VEGFR-3 mRNA was significantly upregulated inVEGF-C156S mice compared to DSS-treated mice after induction of colitis (42.0±1.4vs 3.5±0.4, P<0.001).