The AD-VEGF-C-treated mice had asignificantly larger lymphatic vessel size compared to DSS-treated mice (1974.6±104.3to 1639.0±91.5, P<0.001; Figure 3D).Similarly, the VEGF-C156S-treated mice had a significantly larger lymphatic vesselsize as compared to the PBS-treated mice (2690.4±125.8 to 1650.8±93.2, P<0.001;Figure 3E). Here, VEGFA is linked to Alzheimer disease.