DSS-treated mice showed significantly greater histological damage (cellularinfiltration, goblet cell depletion, damage to crypt architecture and submucosaledema) (Figure 2A-b, e, g, i) compared tonormal untreated mice (Figure 2A-a, d).AD-VEGF-C-treated mice and VEGF-C156S-treated mice (Figure 2A-c, f, h, j) also showed greater histological damage compared toDSS-treated mice. The gene discussed is VEGFA; the disease is Alzheimer disease.