In contrast, significant pathways associated with metastatic progression in the G7 DO population included IL-17 pathways for the DMFS gene signature and metabolic and rheumatoid arthritis pathways for the metastasis-correlated genes, including diabetes signaling (p = 7.23x10-4–2.3x10-4; S4 Table). Here, IL17A is linked to rheumatoid arthritis.