Further, the previous microarray study showed that Methyl-CpG Binding Domain Protein 2 (Mbd2), which functions as a transcription repressor of tumor suppressor genes, was expressed higher in the hearts (Table 2 in Reference [7]) and kidneys (Table A1 in Reference [8]) of the S.LEW congenic strain compared with S. The overexpression of these two tumor-related genes suggests that the S.LEW congenic strain could be more susceptible to tumorigenesis. Here, MBD2 is linked to neoplasm.