EPHX2 and herpes simplex infectious disease: These findings mirror those of the effect of ibuprofen in human volunteer studies.[40] Our finding are also in line with those of Palumbo et al that noted virus dependent activation of COX and LOX12/15, and virus inhibition of 14,15-dihydroxyeicosatrienoate (14,15-DiHETrE), an sEH dependent diol, in cowpox (but not parainfluenza or herpes simplex) infection.[41] The lack of 5-LOX activation is consistent with the clinical trial findings that montelukast, which blocks the action of leukotriene D4 (a downstream product of 5-LOX), does not improve outcomes in bronchiolitis.