In a previous study it was found that systemic hemin therapy attenuates blood-brain barrier disruption after intracerebral hemorrhage [66] and our study has shown that by giving hemin to stressed animals there was significant decrease in expression of S100B in brain tissue and this may be explained by the fact that hemin is a very potent HO-1 inducer and its benefits may be attributed to its catalytic activity and to the antioxidant and anti-inflammatory properties of the two breakdown products, bilirubin and CO [66]. Here, S100B is linked to intracerebral hemorrhage.