Furthermore, knockdown (KD) of ATP13A2 in mouse cortical neurons or human neuroblastoma SHSY5Y cells triggers mitochondrial fragmentation and ROS production [22], whereas ATP13A2 deficiency in patient-derived olfactory neurosphere cultures results in Zn2+ dyshomeostasis, which contributes to mitochondrial dysfunction [18]. The gene discussed is ATP13A2; the disease is neuroblastoma.