Finally, in a cellular PD model in which SHSY5Y cells were exposed to the mitochondrial complex I inhibitor rotenone to induce mitochondrial stress, ATP13A2 activity confers cytoprotection, since overexpression of WT ATP13A2, but not a catalytic dead mutant, protects against, whereas KD of ATP13A2 exacerbates cell toxicity [14, 23]. This evidence concerns the gene ATP13A2 and Parkinson disease.