Most transgenic AD mouse models overexpressing different familial AD mutations, such as Tg2576 (APPSwe; K670N/M671L), PDAPP (APPInd; V717F), 3xTg (APPswe, Tau P301L, and PS1 M146V), and 5xFAD (APPswe, APPFlorida; I716V, APPLondon; V717I, PS1 M146L, and PS1 L286V), generally display impairments in LTP and cognition [22–26]. Here, MAPT is linked to Alzheimer disease.