Aβ-induced internalization of NMDARs involves dephosphorylation of the GluN2B subunit at Tyr-1472 by STEP61 (striatal-enriched protein tyrosine phosphatase 61), the expression of which is upregulated in several AD mouse models, as well as in the postmortem prefrontal cortex of AD patients [33, 94–96]. The gene discussed is GRIN2B; the disease is Alzheimer disease.