In this work, we investigated transcriptional profiling of glyco-genes in a HCC-related cell line (HepG2) and correlated the results with the N-linked glycans on glycoproteins secreted from HepG2 cells after the treatment with 5-aza-2dC, the inhibitor of DNA methyltransferase 1 (DNMT1)38. Here, DNMT1 is linked to hepatocellular carcinoma.