Considering that E2 and G-1 trigger the expression of IL1β in CAFs (shown in Fig. 1) and IL1R1 in breast cancer cells (shown in Fig. 2), we then assessed that conditioned medium from CAFs exposed to E2 and G-1 does induce PTGES protein expression in SkBr3 (Fig. 5G–H) and MCF-7 (Fig. 5I,J) cells exposed to E2 or G-1. The gene discussed is IL1R1; the disease is breast cancer.