A literature search was performed for relevant studies between January 2013 and December 2015 using PubMed, the Cochrane Library and EMBASE with the search terms ‘hypertension’, ‘resistant hypertension’, combined sequentially with ‘spironolactone’, ‘eplerenone’, ‘mineralocorticoid receptor blocker’, and ‘mineralocorticoid receptor antagonist’. Here, NR3C2 is linked to hypertensive disorder.