BIRC5 and breast cancer: Our data showed that several anti-apoptosis genes and pro-proliferation genes were involved in pathways downstream of UHRF1, such as BIRC5 and CENPF. BIRC5 is a member of the inhibitor of apoptosis (IAP) family preferentially expressed by many cancers, including BC [10], and its mediated cellular networks are essential for cancer cell proliferation and viability [34].