UHRF1 and breast cancer: We performed quantitative real-time RT-PCR (qRT-PCR) to validate that miR-145-5p and miR-145-3p repressed UHRF1 mRNA expression in BC cell lines, and we did indeed observe that it was significantly reduced in transfectants of these miRNAs in comparison with mock or miR-control transfectants (P < 0.0001 and P = 0.0036, Figure 4A).