EGFR and adenocarcinoma: By multivariate analysis, Cyfra21-1 (HR = 1.543, P = 0.032 for DFS; HR = 2.527, P < 0.001 for OS) and clinical stage (HR = 1.825, P = 0.004 for DFS; HR = 1.694, P = 0.040 for OS) were independent predictive and prognostic factors in all EGFR-mutated adenocarcinoma patients.