Ney et al. 2013 [92] for the first time reported a significant association between the SNP rs3102735 (5′ near promoter region containing the minor allele C as well as for the homo- and heterozygous genotype with the minor allele C) of the OPG gene and the susceptibility of breast cancer in Caucasian populations. The gene discussed is TNFRSF11B; the disease is breast cancer.