By employing a series of lines of knock-out mice, including Rag1−/−, CCR2−/−, LtbrDhep, and IkkBDhep to determine the critical role of intrahepatic CD8+ T cells and NKT cells in the development of NASH-HCC in mice fed CD-HFD, the investigators have employed an innovative approach to dissect LIGHT, the ligand of LTβ receptor (LTβR) (derived from NKT cells) and lymphotoxins released from these two subsets of lymphocytes in the transition from NASH to HCC [43]. This evidence concerns the gene LTBR and hepatocellular carcinoma.