BCL2 and liver cancer: In summary, among all mechanisms found in this study, simultaneous initiation of the intrinsic and extrinsic pathways of apoptosis via series of caspase activity, cell cycle arrest, down-regulation of Bcl-2 and Bcl-xL, up-regulation of p53 and Bax and inhibiting the NF-κB pathway are the most critical effects of PCC on liver cancer cells.