In support of this premise, the minor allele of FOXO3 SNP rs12212067 (which is in linkage disequilibrium with rs2802292 and could act as a proxy) was associated with a milder clinical course of seemingly unrelated inflammatory conditions (Crohn's disease and rheumatoid arthritis) (Lee et al., 2013). The gene discussed is FOXO3; the disease is rheumatoid arthritis.