BRCA1 and ovarian carcinoma: For ovarian cancer, LOF mutations were not enriched in hGIS1 genes (P=0.87) but were enriched in hGIS2 genes (P<0.0001); this increase in significance was due to the presence BRCA1 and BRCA2 in the hGIS2 gene list, which accounted for 70% of the LOF mutations in hGIS2 genes.