BRCA1 and ovarian carcinoma: In the case of the ovarian cancer TCGA data, 23% of the samples with any data had LOF mutations in GIS gene homologues, with 65% of the samples with LOF mutations having LOF mutations in BRCA1 and BRCA2 as previously reported31; no other individual GIS gene homolog had a LOF mutation in >0.5 to 1% of the samples.