It should be noted that the colorectal cancer cases did include cases with alterations in MMR genes (MSH2, MSH6, MSH1 and PMS2), including 46 cases with only LOF mutations and 50 cases with LOF+predicted deleterious missense mutations (19 of these cases had silencing of MLH1, 1 of which also had LOH of MLH1), all but 3 of which had alterations in other GIS genes. This evidence concerns the gene MSH2 and colorectal cancer.