EVs may trigger the immune system depending on their molecular composition and cells of origin, not only by carrying peptide-loaded MHC molecules or tumor and pathogen antigens to antigen presenting cells51, 52, but also by dampening inflammatory response through the exposition of pro-apoptotic molecules, such as CD95L, TRAIL or Galectin-953, 54. The gene discussed is FASLG; the disease is neoplasm.