Recent studies showing colocalization of 37/67 kDa laminin receptor with PrPCWD (Chronic Wasting Disease isoform of PrPC), ovine PrPSc and PrPBSE (Bovine Spongiform Encephalopathy isoform of PrPC)33 together with the finding that bovine prions are endocytosed in an 37/67 kDa LR-dependent manner by human enterocytes34, confirm the relevance of non-integrin laminin receptor in the oral uptake of prions. This evidence concerns the gene PRNP and prion disease.