We observed that Rheb1 mRNA expression was substantially higher in human AMLs, such as AML with t(8;21)(AMLI_ETO), AML with t(15;17)(APL), AML with inv(16)/t(16;16), or AML with t(11q23)/MLL in contrast to normal polymorphonuclear cells (PMN) in the peripheral blood (PB) or bone marrow (BM) (Fig. 1a). Here, KMT2A is linked to acute promyelocytic leukemia.