TP53 and acute myeloid leukemia: Although we observed no obvious difference in the mRNA expression in Rheb1Δ/Δ and WT GFP+ cells (Fig. 4i), the mRNA expression of p53 and Bax was significantly increased in Rheb1Δ/Δ K+G− cells compared with the WT control (Fig. 4j), suggesting that Rheb1 inhibits the apoptosis of AML LSC cells through the repression of the mRNA expression of p53 and Bax.