The deletion of raptor, a core component of mTORC1 [57], in the MLL-AF9 murine leukemia model, inhibited mTORC1 activity as evidenced by the decreased phosphorylation of S6 and 4E-BP1, decreased proliferation, and enhanced apoptosis of AML cells. This evidence concerns the gene EIF4EBP1 and acute myeloid leukemia.