Although we observed no obvious difference in the mRNA expression in Rheb1Δ/Δ and WT GFP+ cells (Fig. 4i), the mRNA expression of p53 and Bax was significantly increased in Rheb1Δ/Δ K+G− cells compared with the WT control (Fig. 4j), suggesting that Rheb1 inhibits the apoptosis of AML LSC cells through the repression of the mRNA expression of p53 and Bax. This evidence concerns the gene RHEBP1 and acute myeloid leukemia.