Interestingly, a previous global analysis of SCD erythrocyte microRNAs identified increased miR-144 levels were associated with increased disease severity; miR-144 downregulates NRF2, which results in lower NRF2 levels, and thus, contributes to SCD erythrocyte reduced oxidative stress capacity [15]. The gene discussed is NFE2L2; the disease is Schnyder corneal dystrophy.