Our results on the incidence of HER2 overexpression (3+ and/or ISH amplification) are well in line with previous results, with a low frequency in pancreatobiliary-type tumours or pancreatic cancer, and a higher frequency in I-type adenocarcinomas, although the latter is lower than in gastric cancer [42]. The gene discussed is ERBB2; the disease is familial pancreatic carcinoma.